Mohammed Mohammed El-Said
Cellular therapy may be the solution of challenging problems in colorectalsurgery such as impaired healing leading to anastomotic
leakage and metastaticcolorectal cancer (CRC). This review aimed to illustrate the role of cellulartherapy in promotion of wound healing
and management of metastatic CRC. Anorganized literature search for the role of cellular therapy in promotion of woundhealing and
management of metastatic CRC was conducted. Electronic databasesincluding PubMed/Medline, Scopus, and Embase were queried
for the searchprocess. Two types of cellular therapy have been recognized, the mesenchymalstem cells (MSCs) and bone marrowmononuclear
cells (BM-MNCs) therapy.These cells have been shown to accelerate and promote healing of various tissueinjuries in
animal and human studies. In addition, experimental studies havereported that MSCs may help suppress the progression of colon
cancer in ratmodels. This article reviews the possible mechanisms of action and clinical utilityof MSCs and BM-MNCs in promotion
of healing and suppression of tumorgrowth in light of the published literature. Cellular therapy has a potentiallyimportant role in
colorectal surgery, particularly in the promotion of woundhealing and management of metastatic CRC. Future directions of cellular
therapyin colorectal surgery were explored which may help stimulate futures studies onthe role of cellular therapy in colorectal
surgery.