Tyler Smith
By altering cellular and molecular processes in the brain, exercise may enhance cognitive function. We contend that a key component of exercise's beneficial effects on the brain is the facilitation of Long-term synaptic Potentiation (LTP)-related pathways by exerkines, which are substances produced as a result of physical activity. This review lists the synaptic pathways that cytokines activate and may enhance LTP. For a total of 16 exerkines, we showed how blood and brain exerkine levels are affected by the type of exercise (e.g., aerobic or resistance exercise) and whether it is repeated several times (i.e., chronic exercise) (i.e., chronic exercise). The creation of customised physical activity routines may be made possible by this information. Last but not least, this study may help to focus future research on basic gaps in our understanding of the biophysical connections between muscle activity and the brain at both the cellular and system levels.