Lampros Varley
Metabolic syndrome frequently manifests as Non-Alcoholic Fatty Liver Disease (NAFLD). Endocrine hormones in addition to lifestyle choices are involved in the dysregulation of hepatic metabolism. Changes in the levels of thyroid hormones (THs), primarily in subclinical hypothyroidism, and sex hormones are the most frequent endocrine hormones causing metabolic syndrome (in menopause). These hormonal adjustments impact hepatic lipid and glucose metabolism and may lead to an increase in hepatic fat deposition. The effects of sex hormones, or THs, and their corresponding stimulating hormones, Thyroid-Stimulating Hormone (TSH) and FollicleStimulating Hormone (FSH), on the onset of hepatosteatosis are compared in this article. FSH and TSH might be when metabolic alterations were discovered while only stimulating hormone levels were aberrant and peripheral hormone levels were still within the normal range, they are more pertinent to the dysregulation of hepatic metabolism than the peripheral hormones. Increased TSH and FSH levels seem to function separately from one another while also having additive effects on the development of NAFLD.