Lawrence M Agius
Dimensions of inclusion within the overall concept of neurodegeneration would appear to arise as inherent consequences of the high metabolic rates of neuronal patho-physiology that dimensionally characterizes the sub-set neuronal populations.
It is valid to consider the essential neurodegenerative state as a highly inclusive pathobiologic state of response to neuronal injury that elicits multiple pathways of apoptosis. It is within the spectral manifestations for further heightened susceptibility that disorders such as Alzheimer’s, Parkinson’s, Huntington’s and also other disorders of the CNS would include also specific manifestations within the further contrasting specificities of disease states such as amyotrophic lateral sclerosis.
Hence, it is beyond specificity issues that the neurodegenerative state projects the overall dimensions of a generic cell injury within the strict confines of highly selective sub-type neuronal pathobiology in terms of the essential progressive manifestations of cell loss.