QiongLiu
Vanadium compounds have been reported to mimic the anti-diabetes effects of insulin in rodent models, but their effects on Alzheimer’s disease (AD) have rarely been explored. Bis(ethylmaltolato)oxovanadium (IV) (BEOV)has pleasant malt-aromad and exhibits insulin-like function with low toxicity and good hypoglycemic effect. In this paper, BEOV was found to improve contextual memory and spatial learning in two types of transgenic AD model mice (3×Tg-AD and APP/PS1). Italso improved glucose metabolism in the AD brains, as evidenced by 18F-labeled fluoro-deoxyglucose positron emission tomography (18F-FDG-PET) scanning. Protection of neuronal synapsesby BEOV was detected by transmission electron microscopy.The dendritic spines of pyramidal neuron in neocortex were detected by in vivo two-photon imaging of AD-YFP mice (the offspring of 3